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© Research
Publication :

Identification and characterization of PDC1, a novel protein involved in the epigenetic cell degeneration Crippled Growth in Podospora anserina.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in - 30 Jul 2018

Nguyen TS, Lalucque H, Silar P

Link to Pubmed [PMID] – 30069939

Mol Microbiol. 2018 Nov;110(4):499-512

The model fungus Podospora anserina exhibits Crippled Growth (CG), a cell degeneration process linked to the spreading of a prion-like hereditary element. Previous work has shown that the PaMpk1 MAP kinase and the PaNox1 NADPH oxidase are key player in setting up CG. Here, we identified PDC1, a new gene that negatively regulates the PaMpk1 pathway, by identifying the gene mutated in the PDC2205 mutant. This mutant exhibits strong CG in conditions where the wild-type does not. PDC1 encodes a small protein conserved in other Pezizomycotina. The protein contains four evolutionary-conserved cysteines, a tryptophan and a histidine; all six amino-acid are essential for function. PDC1 is located in the cytosol and is present in lower amounts in stationary hyphae in accordance with its role as a repressor. Epistasis analyses place PDC1 between PaMpk1 and PaNox1.

https://www.ncbi.nlm.nih.gov/pubmed/30069939