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© Benoît Chassaing
Interaction microbiote-mucus à la surface de l’épithélium colique humain
Publication : Medical hypotheses

Gut Barrier Dysfunction and Type 2 Immunity: Implications for Compulsive Behavior.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Medical hypotheses - 01 Apr 2022

Fields CT, Chassaing B, de Vries GJ

Link to Pubmed [PMID] – 36060122

Link to DOI – 10.1016/j.mehy.2022.110799

Med Hypotheses 2022 Apr; 161():

To date, much of the focus of gut-brain axis research has been on gut microbiota regulation of anxiety and stress-related behaviors. Much less attention has been directed to potential connections between gut microbiota and compulsive behavior. Here, we discuss a potential link between gut barrier dysfunction and compulsive behavior that is mediated through “type 2” rather than “type 1” inflammation. We examine connections between compulsive behavior and type 2 inflammation in Tourette syndrome, obsessive-compulsive disorder, autism, addiction, and post-traumatic stress disorder. Next, we discuss potential connections between gut barrier dysfunction, type 2 inflammation, and compulsive behavior. We posit a potential mechanism whereby gut barrier dysfunction-associated type 2 inflammation may drive compulsive behavior through histamine regulation of dopamine neurotransmission. Finally, we discuss the possibility of exploiting the greater accessibility of the gut relative to the brain in identifying targets to treat compulsive behavior disorders.