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© Mélanie Falord, Tarek Msadek, Jean-Marc Panaud
Staphylococcus aureus "golden staph" in scanning electron microscopy.
Publication : Current opinion in microbiology

Group B Streptococcus surface proteins as major determinants for meningeal tropism

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in microbiology - 27 Dec 2011

Tazi A, Bellais S, Tardieux I, Dramsi S, Trieu-Cuot P, Poyart C

Link to Pubmed [PMID] – 22206860

Curr. Opin. Microbiol. 2012 Feb;15(1):44-9

Streptococcus agalactiae (group B Streptococcus, GBS), a normal constituent of the intestinal microbiota is the major cause of human neonatal infections and a worldwide spread ‘hypervirulent’ clone, GBS ST-17, is strongly associated with neonatal meningitis. Adhesion to epithelial and endothelial cells constitutes a key step of the infectious process. Therefore GBS surface-anchored proteins are obvious potential adhesion mediators of barrier crossing and determinant of hypervirulence. This review addresses the most recent molecular insights gained from studies on GBS surface proteins proven to be involved in the crossing of the brain-blood barrier and emphasizes on the specificity of a hypervirulent clone that displays meningeal tropism.

http://www.ncbi.nlm.nih.gov/pubmed/22206860