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© Institut Pasteur
Culture de myotubes murins infectés par le virus de la rage fixe, observée en immunoflorescence indirecte.
Publication : Annals of the New York Academy of Sciences

Glycoprotein of nonpathogenic rabies viruses is a major inducer of apoptosis in human jurkat T cells

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Annals of the New York Academy of Sciences - 01 Dec 2003

Lay S, Préhaud C, Dietzschold B, Lafon M

Link to Pubmed [PMID] – 15033795

Ann. N. Y. Acad. Sci. 2003 Dec;1010:577-81

This study sought to identify the RV protein that causes apoptosis. For this purpose, we first compared the ability of G and N proteins of a pathogenic and a nonpathogenic strain to trigger apoptosis of Jurkat rtTA by using an inducible Tet-on expression system. Then we analyzed apoptosis induced by a reverse genetic-engineered recombinant rabies virus in which the G gene from a nonpathogenic strain was replaced by its pathogenic strain counterpart. No other virus proteins than G of nonpathogenic RV strains induce apoptosis, and the G polypeptide of RV is a critical determinant for apoptosis in human cells.

http://www.ncbi.nlm.nih.gov/pubmed/15033795