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© Research
Publication : Research in immunology

Extensive structural homology between H-2 K/D/L antigens and non-polymorphic class I Qa, Tla and “37” molecules suggests they may act as peptide carriers

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Research in immunology - 01 Feb 1989

Prochnicka-Chalufour A, Casanova JL, Kourilsky P, Claverie JM

Link to Pubmed [PMID] – 2740613

Res. Immunol. 1989 Feb;140(2):133-44

Key structural features of H-2 K/D/L and HLA A/B/C class I molecules were identified by analysing the available sequences with reference to the 3-D structure of HLA-A2. Most of them were found to be conserved in a panel of 6 Qa and 4 Tla sequences. This finding, in addition to the high overall sequence similarity between polymorphic and non-polymorphic class I molecules strongly suggests a possible role for the latter in peptide binding, transport and/or presentation.

http://www.ncbi.nlm.nih.gov/pubmed/2740613