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© Research
Publication : Annals of the New York Academy of Sciences

Establishing insulin 1 and insulin 2 knockout congenic strains on NOD genetic background

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Annals of the New York Academy of Sciences - 01 Nov 2003

Paronen J, Moriyama H, Abiru N, Sikora K, Melanitou E, Babu S, Bao F, Liu E, Miao D, Eisenbarth GS

Link to Pubmed [PMID] – 14679060

Ann. N. Y. Acad. Sci. 2003 Nov;1005:205-10

As insulin is a major autoantigen in autoimmune diabetes and because the insulin gene region locus in humans has been linked to diabetes risk, we have bred insulin gene knockouts onto the NOD mouse. Mice differ from humans in terms that they express two nonallelic genes of insulin. Insulin 2 is the murine homologue of the human insulin gene and is located on mouse chromosome 7. Insulin 1 is thought to have evolved by a gene duplication event, lacks the second intron of the insulin 2 gene, and is located on mouse chromosome 19. The differential thymic expression of the insulin gene may be important for central tolerance induction. Here, we present the initial establishment of congenic knockouts and characterization of the congenic intervals corresponding to insulin 1 and insulin 2 knockout genes on mouse chromosome 19 and 7, respectively.

http://www.ncbi.nlm.nih.gov/pubmed/14679060