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© Research
Publication : Medecine/Sciences

Epiblast and primitive endoderm cell specification during mouse preimplantation development: a combination between biology and mathematical modeling

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Medecine/Sciences - 25 Feb 2016

Sylvain Bessonnard, Didier Gonze, Geneviève Dupont

Link to Pubmed [PMID] – 26936177

2016;32:192-7

Article en Français

Lors de son implantation dans l’utérus de la mère chez les mammifères, l’embryon est composé de trois tissus morphologiquement distincts : l’épiblaste (Epi), le trophectoderme (TE) et l’endoderme primitif (EPr). L’Epi et l’EPr se forment à partir de la même population cellulaire homogène appelée la masse cellulaire interne (MCI). Le but de nos études, décrites dans cette revue, est de comprendre les interactions moléculaires nécessaires à la mise en place de ces deux lignages. Pour cela, nous avons combiné une approche biologique et une modélisation mathématique. Nous avons ainsi montré le rôle central du groupe de régulation génique NANOG, FGF4, GATA6, FGFR2 pour la spécification de l’Epi et de l’EPr. Il s’agit d’un projet de recherche fondamental, nécessaire pour la compréhension des mécanismes de spécification au sein de l’embryon précoce. Ces recherches peuvent avoir des retombées importantes dans de nombreux autres sujets de recherche, tels que l’amélioration des protocoles de fécondation in vitro et d’assistance médicale à la procréation, mais aussi pour des applications liées à l’utilisation de cellules souches pour la médecine régénératrice.

Upon its implantation in the uterus of the mother in mammals, the embryo is composed by three morphologically distinct tissues: the Epiblast (Epi), the Trophectoderm (TE) and the Primitive Endoderm (PrE). Both Epi and PrE are formed from the same cell homogeneous population called the Inner Cell Mass (ICM). Based on our studies, we discuss in this review what molecular interactions are necessary for the specification of these two lineages. For this, we have combined a biolo- gical approach with mathematical modeling. We have shown the central role of the gene regulation group composed by NANOG, FGF4, GATA6 and FGFR2 for Epi/PrE cell specification.