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© Fabrice Chrétien with Ultrapole, colorized by Jean-Marc Panaud
Cellule souche (en jaune) de muscle squelettique partiellement recouverte par la membrane basale, migrant sur une fibre musculaire (en bleu).
Publication : The journal of gene medicine

Efficient in toto targeted recombination in mouse liver by meganuclease-induced double-strand break

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The journal of gene medicine - 01 May 2006

Gouble A, Smith J, Bruneau S, Perez C, Guyot V, Cabaniols JP, Leduc S, Fiette L, Avé P, Micheau B, Duchateau P, Pâques F

Link to Pubmed [PMID] – 16475243

J Gene Med 2006 May;8(5):616-22

Sequence-specific endonucleases with large recognition sites can cleave DNA in living cells, and, as a consequence, stimulate homologous recombination (HR) up to 10 000-fold. The recent development of artificial meganucleases with chosen specificities has provided the potential to target any chromosomal locus. Thus, they may represent a universal genome engineering tool and seem to be very promising for acute gene therapy. However, in toto applications depend on the ability to target somatic tissues as well as the proficiency of somatic cells to perform double-strand break (DSB)-induced HR.

http://www.ncbi.nlm.nih.gov/pubmed/16475243