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© K. Melican.
Human microvessel (red) colonized by N. meningitidis (green).
Publication : Immunological reviews

Dynamics of the membrane-cytoskeleton interface in MHC class II-restricted antigen presentation

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Immunological reviews - 01 Jul 2016

Bretou M, Kumari A, Malbec O, Moreau HD, Obino D, Pierobon P, Randrian V, Sáez PJ, Lennon-Duménil AM

Link to Pubmed [PMID] – 27319341

Immunol. Rev. 2016 Jul;272(1):39-51

Antigen presentation refers to the ability of cells to show MHC-associated determinants to T lymphocytes, leading to their activation. MHC class II molecules mainly present peptide-derived antigens that are internalized by endocytosis in antigen-presenting cells (APCs). Here, we describe how the interface between cellular membranes and the cytoskeleton regulates the various steps that lead to the presentation of exogenous antigens on MHC class II molecules in the two main types of APCs: dendritic cells (DCs) and B lymphocytes. This includes antigen uptake, processing, APC migration, and APC-T cell interactions. We further discuss how the interaction between APC-specific molecules and cytoskeleton elements allows the coordination of antigen presentation and cell migration in time and space.

https://www.ncbi.nlm.nih.gov/pubmed/27319341