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© Research
Publication : Infectious diseases now

Do not neglect SARS-CoV-2 hospitalization and fatality risks in the middle-aged adult population.

Team: Mathematical Modelling Of Infectious Diseases
Member: Simon Cauchemez
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Infectious diseases now - 01 Jun 2021

Lapidus N, Paireau J, Levy-Bruhl D, de Lamballerie X, Severi G, Touvier M, Zins M, Cauchemez S, Carrat F, ,

Link to Pubmed [PMID] – 33521775

Link to DOI – S2666-9919(20)00032-910.1016/j.idnow.2020.12.007

Infect Dis Now 2021 Jun; 51(4): 380-382

This study aimed at estimating the SARS-CoV-2 infection hospitalization (IHR) and infection fatality ratios (IFR) in France.A serosurvey was conducted in 9782 subjects from the two French regions with the highest incidence of COVID-19 during the first wave of the pandemic and coupled with surveillance data.IHR and IFR were 2.7% and 0.49% overall. Both were higher in men and increased exponentially with age. The relative risks of hospitalization and death were 2.1 (95% CI: 1.9-2.3) and 3.8 (2.4-4.2) per 10-year increase, meaning that IHR and IFR approximately doubled every 10 and 5 years, respectively. They were dramatically high in the very elderly (80-90 years: IHR: 26%, IFR: 9.2%), and also substantial in younger adults (40-50 years: IHR: 0.98%, IFR: 0.042%).These findings support the need for comprehensive preventive measures to help reduce the spread of the virus, even in young or middle-aged adults.