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© Mélanie Falord, Tarek Msadek, Jean-Marc Panaud
Staphylococcus aureus "golden staph" in scanning electron microscopy.
Publication : The ISME journal

Division of labour and terminal differentiation in a novel Bacillus thuringiensis strain

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The ISME journal - 01 Aug 2014

Deng C, Slamti L, Raymond B, Liu G, Lemy C, Gominet M, Yang J, Wang H, Peng Q, Zhang J, Lereclus D, Song F

Link to Pubmed [PMID] – 25083932

ISME J 2015 Feb;9(2):286-96

A major challenge in bacterial developmental biology has been to understand the mechanisms underlying cell fate decisions. Some differentiated cell types display cooperative behaviour. Cooperation is one of the greatest mysteries of evolutionary biology and microbes have been considered as an excellent system for experimentally testing evolution theories. Bacillus thuringiensis (Bt) is a spore-forming bacterium, which is genetically closely related to B. anthracis, the agent of anthrax, and to B. cereus, an opportunistic human pathogen. The defining feature that distinguishes Bt from its relatives is its ability to produce crystal inclusions in the sporulating cells. These toxins are solubilized after ingestion and are cooperative public goods in insect hosts. In this study, we describe a Bt strain LM1212 that presents the unique ability to terminally differentiate into crystal producers and spore formers. Transcriptional analysis based on lacZ and gfp reporter genes suggested that this phenotype is the consequence of a new type of cell differentiation associated with a novel regulation mode of cry gene expression. The differentiating crystal-producer phenotype has higher spore productivity than a typical Bt strain and is better able to compete with Cry toxin null ‘cheaters’. Potentially, this division of labour provides additional fitness benefits in terms of spore viability or durability of Cry toxin.

http://www.ncbi.nlm.nih.gov/pubmed/25083932