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© Pierre Lafaye
Astrocytes marqués par des anticorps VHH anti-GFAP. Des anticorps d'alpagas dirigés contre une protéine spécifique des astrocytes, la GFAP (Glial Fibrillary Acidic Protein), ont été obtenus à partir de camélidés immunisés. La partie VHH (partie de l'anticorps qui reconnaît l'antigène) a été exprimée sous forme recombinante chez Escherichia coli.
Publication : PLoS neglected tropical diseases

Development and evaluation of two simple, rapid immunochromatographic tests for the detection of Yersinia pestis antibodies in humans and reservoirs

Team: Antibody Engineering
Member: Farida Nato
Member: Pierre Lafaye
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PLoS neglected tropical diseases - 28 Apr 2009

Rajerison M, Dartevelle S, Ralafiarisoa LA, Bitam I, Dinh TN, Andrianaivoarimanana V, Nato F, Rahalison L

Link to Pubmed [PMID] – 19399164

PLoS Negl Trop Dis 2009;3(4):e421

Tools for plague diagnosis and surveillance are not always available and affordable in most of the countries affected by the disease. Yersinia pestis isolation for confirmation is time-consuming and difficult to perform under field conditions. Serologic tests like ELISA require specific equipments not always available in developing countries. In addition to the existing rapid test for antigen detection, a rapid serodiagnostic assay may be useful for plague control.

http://www.ncbi.nlm.nih.gov/pubmed/19399164