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© Research
Publication : Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie

[Demonstration of an engagement process towards cell death by apoptosis in lymphocytes of HIV infected patients]

Team: Group: Humanized mice and in vivo analysis of human Plasmodium infections
Member: Marie-Lise Gougeon
Member: Sylvie Garcia
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie - 01 Jan 1991

Gougeon ML, Olivier R, Garcia S, Guetard D, Dragic T, Dauguet C, Montagnier L

Link to Pubmed [PMID] – 1648991

C. R. Acad. Sci. III, Sci. Vie 1991;312(11):529-37

Peripheral blood lymphocytes from AIDS patients or from infected asymptomatic individuals display a rapid loss of viability upon culture in a survival medium. Cellular death occurs following endonucleosomal DNA fragmentation (apoptosis), which is preceeded by chromatin condensation and lower staining with orange acridine. This phenomenon is accelerated by compounds known to activate lymphocytes (such as ionophores) and is partly or entirely suppressed by addition of a cytokine crude preparation, enriched in IL2. All together, these results suggest that in vivo a significant fraction of patients’ lymphocytes is engaged towards a preapoptosis process resulting from abnormal activation.