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© Research
Publication : Frontiers in microbiology

Cytosolic Innate Immune Sensing and Signaling upon Infection.

Team: Group : Bacterial Pathogenesis and Antibacterial Agents
Team: Yersinia
Member: Olivier Dussurget
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Frontiers in microbiology - 01 Jan 2016

Radoshevich L, Dussurget O,

Link to Pubmed [PMID] – 27014235

Link to DOI – 31310.3389/fmicb.2016.00313

Front Microbiol 2016 ; 7(): 313

Cytosolic sensing of pathogens is essential to a productive immune response. Recent reports have emphasized the importance of signaling platforms emanating from organelles and cytosolic sensors, particularly during the response to intracellular pathogens. Here, we highlight recent discoveries identifying the key mediators of nucleic acid and cyclic nucleotide sensing and discuss their importance in host defense. This review will also cover strategies evolved by pathogens to manipulate these pathways.