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whocc
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Assistant Professor
Associate Professor
Clinical Research Assistant
Clinical Research Nurse
Clinician Researcher
Department Manager
Dual-education Student
Full Professor
Honorary Professor
Lab assistant
Master Student
Non-permanent Researcher
Nursing Staff
Permanent Researcher
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PhD Student
Physician
Post-doc
Prize
Project Manager
Research Associate
Research Engineer
Retired scientist
Technician
Undergraduate Student
Veterinary
Visiting Scientist

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Deputy Director of Department
Deputy Director of National Reference Center
Deputy Head of Facility
Director of Center
Director of Department
Director of Institute
Director of National Reference Center
Group Leader
Head of Facility
Head of Operations
Head of Structure
Honorary President of the Departement
Labex Coordinator

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Bacteria have numerous distinctive groups of phage-plasmids with conserved phage and variable plasmid gene repertoires.

Genomic characterization and phylogenetic analysis of the first SARS-CoV-2 variants introduced in Lebanon.

Cellules végétative et spores de Clostridioides difficile / Vegative cells and spores of Clostridioides difficile

Publication : Journal of the American Chemical Society

Cyclic Poly(α-peptoid)s by Lithium bis(trimethylsilyl)amide (LiHMDS)-Mediated Ring-Expansion Polymerization: Simple Access to Bioactive Backbones.

Team: Pathogenesis of Bacterial Anaerobes

Member: Bruno Dupuy

Scientific Fields

Diseases

Organisms

Applications

Technique

Published in Journal of the American Chemical Society - 17 Mar 2021

Salas-Ambrosio P, Tronnet A, Since M, Bourgeade-Delmas S, Stigliani JL, Vax A, Lecommandoux S, Dupuy B, Verhaeghe P, Bonduelle C,

Link to Pubmed [PMID] – 33651603

Link to DOI – 10.1021/jacs.0c13231

J Am Chem Soc 2021 03; 143(10): 3697-3702

Cyclic polymers display unique physicochemical and biological properties. However, their development is often limited by their challenging preparation. In this work, we present a simple route to cyclic poly(α-peptoids) from N-alkylated-N-carboxyanhydrides (NNCA) using LiHMDS promoted ring-expansion polymerization (REP) in DMF. This new method allows the unprecedented use of lysine-like monomers in REP to design bioactive macrocycles bearing pharmaceutical potential against Clostridioides difficile, a bacterium responsible for nosocomial infections.

Published on: 17 Mar 2021 • Modified on: 16 Sep 2021