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© Research
Publication : Nature communications

Cortical recruitment determines learning dynamics and strategy

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature communications - 01 Apr 2019

Ceballo S, Bourg J, Kempf A, Piwkowska Z, Daret A, Pinson P, Deneux T, Rumpel S, Bathellier B

Link to Pubmed [PMID] – 30931939

Nat Commun 2019 04;10(1):1479

Salience is a broad and widely used concept in neuroscience whose neuronal correlates, however, remain elusive. In behavioral conditioning, salience is used to explain various effects, such as stimulus overshadowing, and refers to how fast and strongly a stimulus can be associated with a conditioned event. Here, we identify sounds of equal intensity and perceptual detectability, which due to their spectro-temporal content recruit different levels of population activity in mouse auditory cortex. When using these sounds as cues in a Go/NoGo discrimination task, the degree of cortical recruitment matches the salience parameter of a reinforcement learning model used to analyze learning speed. We test an essential prediction of this model by training mice to discriminate light-sculpted optogenetic activity patterns in auditory cortex, and verify that cortical recruitment causally determines association or overshadowing of the stimulus components. This demonstrates that cortical recruitment underlies major aspects of stimulus salience during reinforcement learning.

https://www.ncbi.nlm.nih.gov/pubmed/30931939