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  • Clinician Researcher
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  • PhD Student
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  • Post-doc
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  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
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  • Director of National Reference Center
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© Research
Publication : Open forum infectious diseases

Continued Sensitivity of Plasmodium falciparum to Artemisinin in Guyana, With Absence of Kelch Propeller Domain Mutant Alleles.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Open forum infectious diseases - 01 Sep 2016

Rahman R, Martin MJ, Persaud S, Ceron N, Kellman D, Musset L, Carter KH, Ringwald P,

Link to Pubmed [PMID] – 27704030

Link to HAL – Click here

Link to DOI – 10.1093/ofid/ofw185

Open Forum Infect Dis 2016 Sep; 3(3): ofw185

Because of concerns about possible emergence of artemisinin resistance strains of Plasmodium falciparum in mining areas of the interior of Guyana, a 7-day artesunate trial was conducted from March to December 2014. The day-3 parasite clearance rate, the efficacy of artesunate at day 28, and polymorphism of Kelch 13 (PfK13)-the marker of artemisinin resistance-were assessed. The study confirmed the continued sensitivity of P. falciparum to artemisinin. A 7-day course of artesunate was 100% efficacious with only 2% (95% confidence interval, .1%-10.9%) of enrolled subjects positive at day 3. All day-0 parasite samples were wild type. Continued resistance monitoring is nevertheless recommended, given the widespread availability and uncontrolled use of artemisinin drugs in mining areas of Guyana.