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© Research
Publication : Molecular immunology

Conserved structural features between HLA-DO beta and -DR beta

Member: Jean-Philippe Corre
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Molecular immunology - 01 Sep 1998

Thibodeau J, Lavoie PM, Samaan A, Corre JP, Sékaly RP, Cazenave PA

Link to Pubmed [PMID] – 9839557

Mol. Immunol. 1998 Sep;35(13):885-93

HLA-DO is a non-classical MHC class II molecule presumed to play a specialized role in the antigen processing pathway. We have modeled the HLA-DO beta-chain and found its overall structure compatible with the one of DR beta. Functional studies further highlighted the similarity between these beta-chains of the class II family of proteins. Indeed, a mixed heterodimer composed of the DR alpha and a chimeric DO beta-chains presented bacterial superantigens to T cells and was shown to interact with CD4. The implications of such structural conservation for the in vivo functions of HLA-DO are discussed.