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© Research
Publication :

Clone 13-infected Aedes aegypti salivary components inhibit Rift Valley fever virus pathogenicity.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in - 01 May 2014

Le Coupanec A, Babin D, Bouloy M, Choumet V.

Microbes Infect. 2014 May;16(5):439-44.

Rift Valley fever virus (RVFV) continues to cause large outbreaks among humans and domestic animals in Africa. RVFV Clone 13, a naturally attenuated clone, is a promising vaccine which was used during the 2009-2010 outbreak in South Africa and played a key role in the control of the disease. In this work, we infected Aedes aegypti mosquitoes with RVFV Clone 13 and prepared salivary gland extracts (SGE). C57BL/6-NRJ male mice were infected with a mixture of SGE infected by Clone 13 and the ZH548 RVFV strain. With the injection of increasing doses of Clone 13-infected SGE, all mice were protected. Our results suggest Clone 13 infected SGE contain unique antiviral components able to counteract the replication of RVFV when injected into vertebrates.