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© Research
Publication : European journal of immunology

Clonal persistence of B lymphocytes in normal mice is determined by variable region-dependent selection

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in European journal of immunology - 01 Sep 1991

Thomas-Vaslin V, Andrade L, Freitas A, Coutinho A

Link to Pubmed [PMID] – 1909646

Eur. J. Immunol. 1991 Sep;21(9):2239-46

Many adult splenic B cells die within 1 week in the spleen of adoptive adult recipient mice; in contrast, the cellular environment of newborn recipients allows for their expansion and persistence for several weeks. In the present study, we show that the local environment of adult peritoneal cavity also allows adult splenic B cells to persist for over 2 weeks after intraperitoneal transfer. In order to determine whether the persistence of donor B cells in newborn hosts and in the peritoneum of adult recipients results from a selection process involving the clonal specificities expressed, the variation in time of VH gene family repertoires of donor B cells was analyzed in the hosts. At different times after the transfer of splenic cells from lipopolysaccharide (LPS)-reactive mice into LPS-non responder histocompatible recipients, mRNA colony blot assays were performed. The results show that among the donor adult LPS-reactive B cells, the VH genes are differently used by the expanding or persisting B cells, in both kinds of recipients. Thus, cells expressing J558 or VH11 gene families are, in particular, positively selected, while those expressing D-proximal or J606 and 36-30 VH gene families are less selected. These findings demonstrate that the propensity of B cells to persist and expand is determined by their selection through their immunoglobulin variable regions, rather than by genetic properties linked to particular B cell subsets.

http://www.ncbi.nlm.nih.gov/pubmed/1909646