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© Research
Publication : Frontiers in bioscience : a journal and virtual library

Cell cycle dysregulation by HTLV-I: role of the tax oncoprotein

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Frontiers in bioscience : a journal and virtual library - 01 Jan 2002

Neuveut C, Jeang KT

Link to Pubmed [PMID] – 11779707

Front. Biosci. 2002 Jan;7:d157-63

HTLV-I is a human retrovirus which is the etiological agent for adult T-cell leukemia. The virus encodes a 40 kDa oncoprotein, Tax, which has no cellular counterpart. Findings from several laboratories over the past decade have shown that over-expression of the Tax oncoprotein is wholly sufficient to transform animal cells. Emerging evidence supports that Tax transforms cells through dysregulation of several cell cycle checkpoints. Here, we review extant data on how Tax targets cyclins, inhibitors of cyclin dependent kinase, as well as cellular sentries for DNA-damage.

http://www.ncbi.nlm.nih.gov/pubmed/11779707