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© Pierre Lafaye
Astrocytes marqués par des anticorps VHH anti-GFAP. Des anticorps d'alpagas dirigés contre une protéine spécifique des astrocytes, la GFAP (Glial Fibrillary Acidic Protein), ont été obtenus à partir de camélidés immunisés. La partie VHH (partie de l'anticorps qui reconnaît l'antigène) a été exprimée sous forme recombinante chez Escherichia coli.
Publication : Vaccine

Biological diagnosis of meningococcal meningitis in the African meningitis belt: current epidemic strategy and new perspectives

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Vaccine - 07 May 2007

Chanteau S, Rose AM, Djibo S, Nato F, Boisier P

Link to Pubmed [PMID] – 17517452

Vaccine 2007 Sep;25 Suppl 1:A30-6

Laboratory diagnosis is an essential component in surveillance of meningococcal epidemics, as it can inform decision-makers of the Neisseria meningitidis serogroup(s) involved and the most appropriate vaccine to be selected for mass vaccination. However, countries most affected face real limitations in laboratory diagnostics, due to lack of resources. We describe current diagnostic tools and examine their cost-effectiveness for use in an epidemic context. The conclusion is that current WHO recommendations to use only the latex agglutination assay (Pastorex) at epidemic onset is cost-effective, but recently developed rapid diagnostic tests for the major epidemic-causing meningococcal serogroups may prove a breakthrough for the future.

http://www.ncbi.nlm.nih.gov/pubmed/17517452