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© Therese Couderc, Marc Lecuit
Publication : The Journal of antimicrobial chemotherapy

Antifungal drugs during pregnancy: an updated review

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of antimicrobial chemotherapy - 08 Sep 2014

Pilmis B, Jullien V, Sobel J, Lecuit M, Lortholary O, Charlier C

Link to Pubmed [PMID] – 25204341

J. Antimicrob. Chemother. 2015 Jan;70(1):14-22

Antifungal prescription remains a challenge in pregnant women because of uncertainties regarding fetal toxicity and altered maternal pharmacokinetic parameters that may affect efficacy or increase maternal and fetal toxicity. We present updated data reviewing the available knowledge and current recommendations regarding antifungal prescription in pregnancy. Amphotericin B remains the first-choice parenteral drug in spite of its well-established toxicity. Topical drugs are used throughout pregnancy because of limited absorption. Recent data have clarified the teratogenic effect of high-dose fluconazole during the first trimester and provided reassuring cumulative data regarding its use at a single low dose in this key period. Recent data have also provided additional safety data on itraconazole and lipidic derivatives of amphotericin B. Regarding newer antifungal drugs, including posaconazole and echinocandins, clinical data are critically needed before considering prescription in pregnancy.

http://www.ncbi.nlm.nih.gov/pubmed/25204341