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© Christine Schmitt, Anubis Vega Rua, Jean-Marc Panaud
Tête de moustique femelle Aedes albopictus, vecteur du virus de la dengue et du chikungunya. Microphotographie électronique à balayage, image colorisée.
Publication : Journal of virology

An orbivirus of mosquitoes which induces CO2 sensitivity in mosquitoes and is lethal for rabbits

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of virology - 01 Sep 1988

Vazeille MC, Rosen L, Guillon JC

Link to Pubmed [PMID] – 3136255

J. Virol. 1988 Sep;62(9):3484-7

An orbivirus, JKT-7400, isolated from Culex mosquitoes in Indonesia, replicated to a high titer and induced cytopathic effects in Aedes albopictus cell cultures. The virus produced lethal sensitivity to carbon dioxide in Culex and Aedes mosquitoes as well as in Drosophila melanogaster fruit flies but was not the agent of the hereditary sensitivity to carbon dioxide previously described for Culex quinquefasciatus. When injected intravenously in high doses, JKT-7400 virus was lethal for rabbits, apparently without replicating to a significant extent. It was not pathogenic for adult mice inoculated intravenously or for adult or suckling mice inoculated intracerebrally and intraperitoneally. Unlike an orbivirus isolated from Culex mosquitoes in China, JKT-7400 did not interfere with the replication of Japanese encephalitis virus in mosquitoes.

http://www.ncbi.nlm.nih.gov/pubmed/3136255