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© Research
Publication : Microbiology (Reading, England)

An iron-regulated LysR-type element mediates antimicrobial peptide resistance and virulence in Yersinia pseudotuberculosis

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Microbiology (Reading, England) - 23 Apr 2009

Arafah S, Rosso ML, Rehaume L, Hancock RE, Simonet M, Marceau M

Link to Pubmed [PMID] – 19389764

Microbiology (Reading, Engl.) 2009 Jul;155(Pt 7):2168-81

During the course of its infection of the mammalian digestive tract, the entero-invasive, Gram-negative bacterium Yersinia pseudotuberculosis must overcome various hostile living conditions (notably, iron starvation and the presence of antimicrobial compounds produced in situ). We have previously reported that in vitro bacterial growth during iron deprivation raises resistance to the antimicrobial peptide polymyxin B; here, we show that this phenotype is mediated by a chromosomal gene (YPTB0333) encoding a transcriptional regulator from the LysR family. We determined that the product of YPTB0333 is a pleiotropic regulator which controls (in addition to its own expression) genes encoding the Yfe iron-uptake system and polymyxin B resistance. Lastly, by using a mouse model of oral infection, we demonstrated that YPTB0333 is required for colonization of Peyer’s patches and mesenteric lymph nodes by Y. pseudotuberculosis.

http://www.ncbi.nlm.nih.gov/pubmed/19389764