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© Research
Publication : Science (New York, N.Y.)

Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain function.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 03 Oct 2014

Baruch K, Deczkowska A, David E, Castellano JM, Miller O, Kertser A, Berkutzki T, Barnett-Itzhaki Z, Bezalel D, Wyss-Coray T, Amit I, Schwartz M,

Link to Pubmed [PMID] – 25147279

Link to DOI – 10.1126/science.1252945

Science 2014 Oct; 346(6205): 89-93

Aging-associated cognitive decline is affected by factors produced inside and outside the brain. By using multiorgan genome-wide analysis of aged mice, we found that the choroid plexus, an interface between the brain and the circulation, shows a type I interferon (IFN-I)-dependent gene expression profile that was also found in aged human brains. In aged mice, this response was induced by brain-derived signals, present in the cerebrospinal fluid. Blocking IFN-I signaling within the aged brain partially restored cognitive function and hippocampal neurogenesis and reestablished IFN-II-dependent choroid plexus activity, which is lost in aging. Our data identify a chronic aging-induced IFN-I signature, often associated with antiviral response, at the brain’s choroid plexus and demonstrate its negative influence on brain function, thereby suggesting a target for ameliorating cognitive decline in aging.

https://pubmed.ncbi.nlm.nih.gov/25147279