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© Research
Publication : Cell reports. Medicine

Adjunct Immunotherapies for the Management of Severely Ill COVID-19 Patients.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cell reports. Medicine - 19 May 2020

Bonam SR, Kaveri SV, Sakuntabhai A, Gilardin L, Bayry J,

Link to Pubmed [PMID] – 32562483

Link to DOI – 10.1016/j.xcrm.2020.100016

Cell Rep Med 2020 May; 1(2): 100016

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It has infected millions, with more than 275,000 fatal cases as of May 8, 2020. Currently, there are no specific COVID-19 therapies. Most patients depend on mechanical ventilation. Current COVID-19 data clearly highlight that cytokine storm and activated immune cell migration to the lungs characterize the early immune response to COVID-19 that causes severe lung damage and development of acute respiratory distress syndrome. In view of uncertainty associated with immunosuppressive treatments, such as corticosteroids and their possible secondary effects, including risks of secondary infections, we suggest immunotherapies as an adjunct therapy in severe COVID-19 cases. Such immunotherapies based on inflammatory cytokine neutralization, immunomodulation, and passive viral neutralization not only reduce inflammation, inflammation-associated lung damage, or viral load but could also prevent intensive care unit hospitalization and dependency on mechanical ventilation, both of which are limited resources.

https://pubmed.ncbi.nlm.nih.gov/32562483