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© K. Melican.
Human microvessel (red) colonized by N. meningitidis (green).
Publication : Nature communications

Actin nucleation at the centrosome controls lymphocyte polarity

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature communications - 18 Mar 2016

Obino D, Farina F, Malbec O, Sáez PJ, Maurin M, Gaillard J, Dingli F, Loew D, Gautreau A, Yuseff MI, Blanchoin L, Théry M, Lennon-Duménil AM

Link to Pubmed [PMID] – 26987298

Nat Commun 2016 Mar;7:10969

Cell polarity is required for the functional specialization of many cell types including lymphocytes. A hallmark of cell polarity is the reorientation of the centrosome that allows repositioning of organelles and vesicles in an asymmetric fashion. The mechanisms underlying centrosome polarization are not fully understood. Here we found that in resting lymphocytes, centrosome-associated Arp2/3 locally nucleates F-actin, which is needed for centrosome tethering to the nucleus via the LINC complex. Upon lymphocyte activation, Arp2/3 is partially depleted from the centrosome as a result of its recruitment to the immune synapse. This leads to a reduction in F-actin nucleation at the centrosome and thereby allows its detachment from the nucleus and polarization to the synapse. Therefore, F-actin nucleation at the centrosome–regulated by the availability of the Arp2/3 complex–determines its capacity to polarize in response to external stimuli.

https://www.ncbi.nlm.nih.gov/pubmed/26987298