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© Artur Scherf
Scanning Electron Microscopy of Red Blood Cell infected by Plasmodium falciparum.
Publication : International journal of pharmaceutics

A UV-Raman spectrometry method for quality control of anticancer preparations: Results after 18 months of implementation in hospital pharmacy

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in International journal of pharmaceutics - 06 Jan 2016

Nardella F, Beck M, Collart-Dutilleul P, Becker G, Boulanger C, Perello L, Gairard-Dory A, Gourieux B, Ubeaud-Séquier G

Link to Pubmed [PMID] – 26772534

Int J Pharm 2016 Feb;499(1-2):343-350

In France, chemotherapy preparation units of hospital pharmacy compound cytotoxic infusion bags adapted to each patient. The narrow therapeutic index of these preparations led us to implement qualitative and quantitative control for patients’ safety. To this aim, we calibrated an equipment combining UV-vis spectrometry and Raman spectroscopy (QC Prep+) and monitored 14 different molecule-solvent combinations over a 18 months period. This rapid and specific method allowed the qualitative and quantitative analysis of 1 mL sample tests in less than 2 min. On 5742 anticancer preparations, we obtained accepted results with more than 99.4% solvent identification, 99.6% drug identification and only 1.52% of preparations not matching quantitative specifications (±15% of theoretical concentration). This quantitative control enabled us to pinpoint some critical points of production for two of the most common preparations. We thus updated the procedures of reconstitution and preparation, increasing the quality of final product. UV-Raman spectrometry is thus an effective tool to control chemotherapy infusions and to improve good practices of preparation.

https://www.ncbi.nlm.nih.gov/pubmed/26772534