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© Pierre Lafaye
Astrocytes marqués par des anticorps VHH anti-GFAP. Des anticorps d'alpagas dirigés contre une protéine spécifique des astrocytes, la GFAP (Glial Fibrillary Acidic Protein), ont été obtenus à partir de camélidés immunisés. La partie VHH (partie de l'anticorps qui reconnaît l'antigène) a été exprimée sous forme recombinante chez Escherichia coli.
Publication : Transactions of the Royal Society of Tropical Medicine and Hygiene

A five-year field assessment of rapid diagnostic tests for meningococcal meningitis in Niger by using the combination of conventional and real-time PCR assays as a gold standard

Team: Antibody Engineering
Member: Farida Nato
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Transactions of the Royal Society of Tropical Medicine and Hygiene - 02 Dec 2013

Collard JM, Wang X, Mahamane AE, Idi I, Issaka B, Ousseni M, Mayer LW, Nato F, Moulia-Pelat JP

Link to Pubmed [PMID] – 24300442

Trans. R. Soc. Trop. Med. Hyg. 2014 Jan;108(1):6-12

Meningococcocal meningitis represents an important cause of mortality and morbidity in sub-Saharan countries. Confirmatory bacteriological or molecular diagnosis is essential for patient management/treatment and meningitis surveillance, but many laboratory tests are expensive and rarely available for low-income countries. A rapid diagnostic test (RDT) represents a valuable alternative to improve case management and surveillance.

http://www.ncbi.nlm.nih.gov/pubmed/24300442