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© K. Melican.
Human microvessel (red) colonized by N. meningitidis (green).
Publication : Advances in immunology

A critical role for cell polarity in antigen extraction, processing, and presentation by B lymphocytes

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Advances in immunology - 01 Jan 2014

Obino D, Lennon-Duménil AM

Link to Pubmed [PMID] – 24840947

Adv. Immunol. 2014;123:51-67

The activation of B lymphocytes in response to external stimuli represents a key step in the adaptive immune response, which is required for the production of high-affinity antibodies and for the generation of long-term memory. Because the dysregulation of B lymphocyte responses can lead to diverse pathological situations, B cells are considered today as valuable therapeutic targets for immunomodulation, in particular in the context of autoimmune reactions. Here, we review the fundamental molecular and cell biological mechanisms that enable B cells to efficiently sense, acquire, and respond to extracellular antigens. A special emphasis is given to cell polarity, which was shown to be critical for the regulation of antigen acquisition, processing, and presentation by B lymphocytes. How cell polarity coordinates the various steps of B lymphocyte activation and might impact the humoral immune response is further discussed.

https://www.ncbi.nlm.nih.gov/pubmed/24840947