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© Research
Publication : Journal of hepatocellular carcinoma

A Comparison of Presentation, Treatment, and Survival After Hepatocellular Carcinoma of Viral and Non-Viral Etiology in Damietta, Egypt, 2007-2019.

Team: Epidemiology of Emerging Diseases
Member: Arnaud Fontanet
Member: Laura Tondeur
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of hepatocellular carcinoma - 01 Jan 2024

Jean K, Tawheed A, Luong Nguyen LB, Heikal T, Eldaly U, Gaber Elhadidy N, Elghaieb A, Aboudonia A, Tondeur L, Dublineau A, Fontanet A, El-Kassas M

Link to Pubmed [PMID] – 38835726

Link to DOI – 10.2147/JHC.S455832

J Hepatocell Carcinoma 2024 ; 11(): 997-1004

The difference in prognosis between patients diagnosed with viral versus non-viral hepatocellular carcinoma (HCC) in Egypt remains unclear.We used data from patients diagnosed with HCC between 2007 and 2019 from a large monocentric retrospective cohort at the Damietta Oncology referral center (northern Egypt). Presentation and treatment were compared between viral versus non-viral etiology HCC patients. Survival was compared relying on univariate and multivariate Cox regressions.Data from 4714 HCC patients were analyzed. Among them, 204 (4.3%) presented with a non-viral etiology. Patients with non-viral versus viral etiology had a similar presentation overall, especially regarding the BCLC stage at HCC diagnosis. After controlling for various individual characteristics, patients with non-viral versus viral etiology had poorer survival (adjusted Hazard Ratio: 1.244; 95% Confidence Interval: 1.069-1.447).Despite similar features, patients with non-viral- related HCC had poorer survival compared to patients with viral-related HCC.