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Deputy Director of Department
Deputy Director of National Reference Center
Deputy Head of Facility
Director of Center
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Three families of Asgard archaeal viruses identified in metagenome-assembled genomes

Endowing universal CAR T-cell with immune-evasive properties using TALEN-gene editing.

Scanning electron micrograph of Saccharolobus islandicus cells (light blue) infected with the lemon-shaped virus STSV2 (yellow). Artistic rendering by Ala Krupovic.

Publication : Nature Microbiology

A closed Candidatus Odinarchaeum chromosome exposes Asgard archaeal viruses

Team: Archaeal Virology

Member: Mart Krupovic

Scientific Fields

Diseases

Organisms

Applications

Technique

Published in Nature Microbiology - 01 Jul 2022

Tamarit D, Caceres EF, Krupovic M, Nijland R, Eme L, Robinson NP, Ettema TJG

Link to Pubmed [PMID] – 35760836

Link to DOI – 10.1038/s41564-022-01122-y

Nat Microbiol 2022 Jul; 7(7): 948-952

Asgard archaea have recently been identified as the closest archaeal relatives of eukaryotes. Their ecology, and particularly their virome, remain enigmatic. We reassembled and closed the chromosome of Candidatus Odinarchaeum yellowstonii LCB_4, through long-range PCR, revealing CRISPR spacers targeting viral contigs. We found related viruses in the genomes of diverse prokaryotes from geothermal environments, including other Asgard archaea. These viruses open research avenues into the ecology and evolution of Asgard archaea.

Published on: 01 Jul 2022