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© Research
Publication : Biochimie

1H NMR study of the structure of a pyridocarbazole dimer-d[CpGpCpG] complex

Team: Archived: Nuclear Magnetic Resonance Of Biomolecules
Member: Muriel Delepierre
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Biochimie - 01 Jul 1985

Delbarre A, Delepierre M, Igolen J, Le Pecq JB, Roques BP

Link to Pubmed [PMID] – 4084605

Biochimie 1985 Jul-Aug;67(7-8):823-8

The structure of the complexes formed between a 7H-pyridocarbazole dimer (ditercalinium) or the corresponding monomer and d[CpGpCpG] is analyzed in aqueous solution by 270 MHz 1H NMR. In both cases the strong upfield shifts observed on most aromatic resonances are assigned to the formation of intercalated complexes. Bisintercalation of the dimer in the tetranucleotide minihelix is then observed at pH 5.5. The observation of intermolecular negative NOEs induced to some drug resonances by irradiation of sugar protons confirms these conclusions. The orientation of the ligand in the intercalation site is discussed.