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© William Beaucardet
Consultation au Centre médical de l'Institut Pasteur (CMIP).
Publication : Plos One

Transversal sero-epidemiological study of Bordetella pertussis in Tehran, Iran

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Plos One - 01 Sep 2020

Gaelle Noel, Farzad Badmasti, Vajihe S Nikbin, Seyed M Zahraei, Yoann Madec, David Tavel, Mohand Aït-Ahmed, Nicole Guiso, Fereshteh Shahcheraghi, Fabien Taieb

Link to Pubmed [PMID] – 32870922

Link to DOI [DOI] – 10.1371

PLoS One . 2020 Sep 1;15(9)

Objectives: Pertussis remains endemic despite high vaccine coverage in infants and toddlers. Pertussis vaccines confer protection but immunity wanes overtime and boosters are needed in a lifetime. Iran, eligible for the Expanded Program on Immunization that includes the primary immunization, implemented two additional booster doses using a whole-cell vaccine (wPV) at 18 months-old and about 6 years-old. Duration of protection induced by the wPVs currently in use and their impact as pre-school booster are not well documented. This study aimed at assessing vaccination compliance and at estimating the duration of protection conferred by vaccination with wPV in children aged < 15 years in Tehran, Iran.

Methods: Detailed information on vaccination history and capillary blood samples were obtained from 1047 children aged 3-15 years who completed the 3 doses-primary pertussis immunization, in Tehran. Anti-pertussis toxin IgG levels were quantified by ELISA.

Results: Compliance was very high with 93.3% of children who received the three primary and 1st booster doses in a timely manner. Timeliness of the 2nd booster was lower (63.3%). Rate of seropositive samples continuously and significantly increased from 1-2 to 5-6 years after 1st booster attaining 30.4% of children exhibiting serological sign of recent contact with B. pertussis. Second booster dating back 1 or 2 years was associated with high antibody titers, which significantly decreased within 3 years from injection. Among children who received 2nd booster injection more than 2 years before serum analysis, seroprevalence of pertussis infection was 8.4% and seropositivity rate was higher from the 10 years-old group.

Conclusion: Seropositivity in children aged 6-7 years with no 2nd booster supports the need for a vaccination at that age. Adolescent booster may also be considered.