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© Research
Publication : Transcription

10-million-years AGO: argonaute on chromatin in yeast and human, a conserved mode of action?

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Transcription - 12 Apr 2013

Harel-Bellan A, Zazoua MA, Rachez C, Muchardt C, Batsché E

Link to Pubmed [PMID] – 23584094

Transcription 2013 May-Jun;4(3):89-91

Whereas in yeast the function and mode of action of nuclear RNAi are well documented, mammalian nuclear RNAi is a matter of debates. Several papers support a role for nuclear Argonaute in alternative splicing. However, the molecular mechanism remains elusive. Here, we discuss the human nuclear RNAi mechanism in light of what is known of the yeast process.

http://www.ncbi.nlm.nih.gov/pubmed/23584094