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2014Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans, Antimicrob. Agents Chemother. 2015 Feb;59(2):950-9.
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2014Development of diaminoquinazoline histone lysine methyltransferase inhibitors as potent blood-stage antimalarial compounds, ChemMedChem 2014 Oct;9(10):2360-73.
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2014Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria, Nature 2014 Sep;513(7518):431-5.
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2014Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures, Nat. Med. 2014 Mar;20(3):307-12.
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2013Comprehensive histone phosphorylation analysis and identification of Pf14-3-3 protein as a histone H3 phosphorylation reader in malaria parasites, PLoS ONE 2013;8(1):e53179.
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2012Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum, Proc. Natl. Acad. Sci. U.S.A. 2012 Oct;109(41):16708-13.
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2009Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds, J. Biol. Chem. 2009 Sep;284(39):26999-7009.
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2009Host cell entry by apicomplexa parasites requires actin polymerization in the host cell, Cell Host Microbe 2009 Mar;5(3):259-72.
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2008Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum, J. Med. Chem. 2008 Jun;51(12):3649-53.
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2008Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies, Mol. Microbiol. 2008 Apr;68(1):37-50.
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2008Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase, Biochemistry 2008 Feb;47(8):2466-75.
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2007Detergent-dependent kinetics of truncated Plasmodium falciparum dihydroorotate dehydrogenase, J. Biol. Chem. 2007 Apr;282(17):12678-86.
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2006Regulation of surface coat exchange by differentiating African trypanosomes, Mol. Biochem. Parasitol. 2006 Jun;147(2):211-23.
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2005High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase, J. Biol. Chem. 2005 Jun;280(23):21847-53.
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2003Dissociation of cGMP accumulation and relaxation in myometrial smooth muscle: effects of S-nitroso-N-acetylpenicillamine and 3-morpholinosyndonimine, Cell. Signal. 2003 Aug;15(8):763-72.
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2002Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity, J. Biol. Chem. 2002 Nov;277(44):41827-34.
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2001NO-induced relaxation of labouring and non-labouring human myometrium is not mediated by cyclic GMP, Br. J. Pharmacol. 2001 Sep;134(1):206-14.
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2001Secretion of a nucleoside diphosphate kinase (Nm23-H2) by cells from human breast, colon, pancreas and lung tumors, Proc. West. Pharmacol. Soc. 2001;44:61-3.
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2001Ellagic acid inhibits nucleoside diphosphate kinase-B activity, Proc. West. Pharmacol. Soc. 2001;44:57-9.
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2001Actions of S-nitroso N-acetyl penicillamine and 3-morpholinosydonimine may involve disparate signaling pathways in myometrial smooth muscle, Proc. West. Pharmacol. Soc. 2001;44:53-6.