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  • program_project
  • nrc
  • whocc
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  • tool
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  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
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  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
06
Mar 2015
Ending Date
10
Mar 2017
Status
Completed
Members
4
Structures
1
Publications
3

About

Externe collaboration with Genomic, Structure and Translation team of Olivier Namy

 

Translation fidelity is essential for the correct decoding of genetic information. However, translation fidelity is not maximal, and several genes use alternative mechanisms to regulate their expression.  Genome-wide translational analyses, such as ribosome profiling, can identify many features affecting translational quality, such as ribosomal pauses, dual coding regions, translation start sites at AUG or non-AUG codons or unconventional translational decoding events, the translation of non-coding RNA and translational ambiguities.



Ribosome profiling has been widely adopted by the scientific community, because it has revolutionised the ways in which translation can be studied. It can be used for both quantitative and qualitative analyses of translation.



The Genomic, Structure and Translation Team of the Institut de Biologie de la Cellule (Université Paris-Saclay – CNRS) use ribosome profiling approach for understanding translation fidelity in yeast and human cells.

 

 

Nicholas T. Ingolia. Ribosome profiling: new views of translation, from single codons to genome scale. Nature Reviews Genetics 15, 205–213 (2014)

 

References