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© Emmanuel Lemichez
Microscopy image showing the formation of large tunnels in a blood vessel endothelial cell induced by a group of bacterial toxins
Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
23
Jul 2019
Status
Ongoing
Members
4
Structures
2

About

A large number of pathogenic bacteria, notably toxigenic strains of bacteria, reside or pass through the digestive compartment. Some toxins act systemically. Their passage through the epithelial barrier, the first essential step in the process of systemic dissemination, remains to be elucidated.

This process of toxin translocation is an essential step especially in food botulism and in intestinal colonization. Our recent studies highlight the implication of a specific mechanism of transcytosis of botulinum toxins type A and B and the involvement of different enteric cell types that we seek to better characterize. In parallel, we develop diagnostic strategies for rapid determination of isoforms of botulinum toxins in order to better manage patients.