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  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Starting Date
07
Sep 2015
Ending Date
07
Jan 2021
Status
Ongoing
Members
4
Structures
2
Publications
3

About

In Salmonella enterica serovar Typhimurium and many other Gram negative bacteria, SigmaS (RpoS) activates global gene expression and controls adaptive functions including stress resistance, biofilm formation and virulence. SigmaS also downregulates housekeeping metabolic and membrane functions. Downregulation by SigmaS might target genes that are deleterious for persistence of nongrowing cells when they are fully expressed. Understanding the mechanisms by which full expression of these genes results in a fitness cost might provide novel insights into the survival mechanisms and evolution of non-actively growing bacterial populations, with important implications for antibacterial strategies.

Fundings

References