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© A. Alanio, E. Perret
Prolifération de Cryptococcus neoformans dans des macrophages murins.
Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
24
Aug 2015
Status
Ongoing
Members
2
Structures
3
Instituts
1

About

PreCASA LogoPreCASA (Pre-Antiretroviral Therapy Cryptococcal Antigen Screening in AIDS) is a prospective cohort study in Yaounde, Cameroon on severely immunosuppressed HIV-infected patients entering the local antiretroviral therapy (ART) program at less than 100 CD cell count. This study, which is the first in West-Central Africa, aims at implementing and evaluating pre-ART cryptococcal antigen screening at the Day Hospital of the Yaounde Central Hospital, as a strategy to decrease morbidity and mortality linked to HIV-associated cryptococcal meningitis, which remains the most frequent cause of meningitis in adult HIV patients in Sub-Saharan Africa. All screened patients would be followed up for one year, so as to evaluate the risk of development of cryptococcal meningitis. 

It is a study on 400 patients in collaboration with the Infection and immunity research institute of the St Georges University of London and supported financially by France Recherche Nord & Sud Sida-hiv Hepatites (ANRS 12312 PreCASA).

External collaboration: Pr Tom Harrison (UK), Dr Marie Christine Fonkoua (Centre Pasteur du Cameroun), Dr Charles Kouanfack (Hôpital central Yaoundé, Cameroun)

Fundings