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  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
02
Jan 2003
Ending Date
31
Dec 2016
Status
Ongoing
Members
2
Structures
1
Publications
4

About

Why is it important to study the phylogeny of pathogenic fungi. Identification of fungi relied for many years on macroscopic and microscopic morphology on different culture media, it is now almost completely based on sequence homology with the caveat that not all the experts agree on the percentage of difference that separate one species from another. The multiplication of the names (teleomorphes, anamorphes, synonyms …) and the continuous changes have been very confusing especially for the clinicians who are very reluctant to accept changes of names without a demonstration that it relies not only on a few morphological or even nucleotide differences but differences that can impact the management of the patients. Experts in taxonomy have often limited access to clinical and epidemiological data. In that regard, the collection of fungi we built for the past 15 years at the National Reference Center for Invasive Mycoses and Antifungals is very unique in that it contains more than than 5000 isolates of yeasts corresponding to 27 genera and 81 species, and more than 1500 isolates of filamentous fungi corresponding to 77 genera and 257 species, all associated with metadata.

We are focusing on specific groups of fungi (Mucorales, Fusarium, Scedosporium, phaeohyphomycetes) . The objective of the studies is to analyze the diversity of the species causing invasive infections diagnosed in France, but also analyze whether specific species or genotypes are associated with specific presentation and/or outcome.

External Collaborations: Jose Cano (Universitat Rovira i Virgili, Reus, Spain), Sybren de Hoog (CBS Fungal Biodiversity Center, Utrecht, The Netherlands), Lizel Mostert (Stellenbosch University, Matieland, South Africa),  Wieland Meyer (Westmead Millennium Institute for Medical Research, Westmead, Australia), Vincent Robert BioAware, Hannut, Belgium).

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References