Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Research
Project

Multi-scale and multi-resolution bio-molecular structure determination by geometric approaches – multiBioStruct

Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
01
Jan 2020
Ending Date
31
Dec 2023
Status
Ongoing
Members
2

About

This project is in the context of Structural Biology, where Distance Geometry (DG) has been proved to be a valid tool for the analysis and the determination of biological structures, such as proteins. The classical application of DG arises in the framework of Nuclear Magnetic Resonance (NMR) experiments, where distances between atom pairs are estimated by the experimental technique, and suitable three-dimensional conformations of the corresponding molecule need to be identified. This problem is NP-hard and was historically tackled via the use of heuristic and meta-heuristic methods; since some years, several partners of the present project are working on a discretization approach for DG which allows to employ a branch-and-prune (BP) algorithm for the identification of three-dimensional conformations. One strong point of this discretization approach is that the DG solution set can be potentially exhaustively enumerated, providing in this way all possible three-dimensional protein conformations fitting with the experimental data. The main idea in this project is to enhance the robustness of such an approach for efficiently dealing with uncertain data, and to extend its domain of applicability to genomics data and Hi-C data.

https://anr.fr/Project-ANR-19-CE45-0019