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  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Starting Date
01
Sep 2017
Ending Date
01
Jan 2020
Status
Ongoing
Members
5
Structures
5
Instituts
1

About

Pathogenic protozoans of the trypanosomatid group still remain a major world health problem. Cycling between insect vectors and mammalian hosts, Trypanosoma cruzi is the causative agent of Chagas disease, while over 20 Leishmania species cause Leishmaniasis. About 6 million are estimated to be infected with Chagas disease in Latin America, with approximately 61 million people at risk. Leishmaniasis, in its different forms, has been detected in 102 countries. Chagas disease has become a worldwide problem and is increasingly detected in the USA, Canada and in many European countries due mainly to population mobility and migration. There is no vaccine and the treatment is long, expensive and difficult to be implemented with multiple daily injections. Moreover, the WHO has reported the emergence of resistant strains. There is therefore an urgent need to develop new therapeutic strategies.

The aim of this project is to develop inhibitors for the protein synthesis machinery of Trypanosomatids whic is essential for cell growth and proliferation. This project is in collaboration with Nilson Zanchin & Beatriz Guimarães from the Laboratory of Proteomics and Protein Engineering at Instituto Carlos Chagas-FIOCRUZ in Brasil and the Chemistry and Biocatalysis Unit at Institut Pasteur-Paris.