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© A. Alanio, E. Perret
Prolifération de Cryptococcus neoformans dans des macrophages murins.
Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
13
Jun 2015
Status
Ongoing
Members
3
Structures
3
Instituts
1

About

A Medical Research Council and France Recherche Nord & Sud Sida-hiv Hepatites (ANRS) funded trial supervised by Tom Harrison (UK) with Olivier Lortholary being principal investigator “north” for Cameroon sites is being implemented in Malawi, Zambia and Cameroon: “ACTA” trial.

ACTA is the largest (680 patients) phase III, randomized, controlled trial for the treatment of HIV-associated cryptococcal meningitis ever performed which evaluates the best antifungal strategy (i.e. oral high dose fluconazole plus flucytosine or one week amphotericin B-based therapy (+ fluconazole or flucytosine) versus the currently recommended two weeks amphotericin B-based therapy.

The primary objective is the assessment of overall survival at 2 weeks per treatment arm, before the introduction of highly active antiretroviral therapy then survival at 10 weeks.

Ancillary studies (pharmacokinetics/pharmacodynamics studies, cost effectiveness analysis, typing of isolates, proteomic and immunological analyses and host genetic studies) will be further developed.

External Collaborations: Prof. Tom Harrison (St Georges Hospital, University of London, UK); Dr MC Fonkoua (Centre Pasteur du Cameroun), Dr Charles Kouanfack (Hôpital central Yaoundé, Cameroun), Dr Yacouba Mapouré (Hôpital général Douala, Cameroun).

Fundings