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© MPI f. Dynamik und Selbstorganisation
Project

Application of IL7-signaling research to guide diagnostic and therapeutic strategies

Team: Networks and Signaling
Member: Thierry Rose
Member: Pascal Bochet
Member: Sophie Goyard
Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
06
Feb 2015
Status
Ongoing
Members
3
Structures
1

About

When the signaling induced by IL-7 is constitutively altered in patients, we observed lymphopenia when the response is reduced (eg AIDS), and leukemia when it is increased (eg acute lymphoblastic leukemia T-ALL). Comparing the expression of signaling proteins and their location profiles between patients and healthy donors allows us to identify the molecular cause of alterations. These elements are used to select the molecular markers for pathology diagnostic or to identify new therapeutic targets.