About
When the signaling induced by IL-7 is constitutively altered in patients, we observed lymphopenia when the response is reduced (eg AIDS), and leukemia when it is increased (eg acute lymphoblastic leukemia T-ALL). Comparing the expression of signaling proteins and their location profiles between patients and healthy donors allows us to identify the molecular cause of alterations. These elements are used to select the molecular markers for pathology diagnostic or to identify new therapeutic targets.