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  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Starting Date
01
Jan 2015
Status
Ongoing
Members
15
Structures
5

About

Fungal infections have emerged over the past three decades as a considerable threat to human health. These deadly fungal infections are almost all due to species from three genera: Aspergillus, Candida and Cryptococcus. The poor prognosis of the systemic infections caused by Aspergillus fumigatus, Candida albicans and Cryptococcus neoformans reflects both delayed diagnosis and the limited efficacy of the existing antifungal arsenal. In this project, we aim to identify and characterize GPI-anchored proteins (GAPs) that play a crucial role in the biology of C. albicans, Cr. neoformans and A. fumigatus as there is evidence that these important, under-studied components of the cell wall may represent suitable targets in the development of novel antifungals, immunotherapeutics and vaccines. Specifically, we aim at obtaining knock-out and overexpression mutant collections for GAP-encoding genes in the three major fungal pathogens; assessing the contribution of GAPs to key events of the fungal life common to these 3 fungal pathogens; and evaluating their role in cell wall biosynthesis and understanding how selected GAPs mediate adherence of fungal pathogens to biotic or abiotic surfaces and have an impact on fungal virulence.