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© Sol-Foulon N.,Prévost M.C.,Schwartz O., Panaud J.M.
Particules du virus du Sida (VIH) bourgeonnant à la surface d'un lymphocyte T CD4. Microscopie electronique à balayage. Image colorisée. Coloured scanning electron micrograph (SEM) of AIDS virus particles at the surface of a lymphocyte T CD4 .
News

“Shieldin” the ends of broken DNA – The Shieldin complex, a new player in DNA repair and response of cancer cells to PARP inhibitors

A successful collaboration between the Deriano lab at the Institut Pasteur, the Jackson lab at the Wellcome Trust/Cancer Research UK Gurdon Institute and the Jacobs lab at the Netherlands Cancer Institute identified the Shieldin complex that affects response of BRCA1-negative cells to PARP inhibitors and promotes immunoglobulin class switch recombination and fusion of unprotected telomeres.

Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells (Nature Cell Biology, published : 18 July 2018).

go.nature.com/2Nn9yCn

Nature Cell Biology