Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Lydie Couturier , Institut Pasteur
Organes sensoriels en développement chez la drosophile
News

SEMINAR ” RNA Therapeutics: Antisense Oligonucleotides for the Treatment of Degenerative Disorders “

Friday 4th November — at 12.00 pm — Amphi J.Monod (Bât.66)

Invited Speaker : Michelle L. Hastings

hastings_photo

From Associate Professor , Chicago Medical School
Rosalind Franklin University of Medicine and Science
Department of Cell Biology and Anatomy

Hosted by Christian Muchardt

Abstract : Therapeutics designed to target RNA offer powerful new strategies for the treatment of disease. Antisense oligonucleotide (ASO) technology is one such RNA-targeting tool that is being used to directly modulate gene expression for therapeutic benefit. We work with a type of ASO that is chemically modified to bind with high-affinity to pre-mRNA and create a steric block to splicing. These so-called splice-switching oligonucleotides (SSOs) are effective at correcting defective splicing associated with disease. In this talk, I will discuss the utility of SSOs as drugs and highlight some of our studies to design and develop therapeutic SSOs for hearing impairment, vestibular dysfunction and vision loss in Usher syndrome and neurodegeneration in Alzheimer’s disease.