Outbreak Investigation Task Force
The recent epidemics of Lassa fever in Nigeria, Ebola virus disease in West Africa, MERS-CoV in the Middle East, Yellow Fever in DRC, Angola and Brazil, avian influenza in Asia and Africa and Zika […]
Dengue virus genotype replacements: investigating viral fitness differences driving the evolution of dengue epidemics Phylogenetic analyses have revealed that dengue virus (DENV) evolutionary dynamics are often characterized by the replacement of a DENV genotype […]
Development and validation of an innovative multiplex molecular diagnostic test for Dengue /Chikungunya Viruses
Description: This project exploits ELOSA (Enzyme-linked OligoSorbent Assay) technology based on patented original polythiolated probes. We will use generic probes and will develop type-specific probes in the ARBO-PLEX Project for DENV and CHIKV. This […]
How novel Nano-biosurfacing constructs can Improve the Diagnosis of Infectious diseases in the PACific region?
Description: A good surveillance must not focus only on human cases but should also focus on the pathogens in their environment. Within this proposal, we aimed to develop and adapt this RDT to vectors, […]
Role of intestinal carriage in the global emergence of multidrug resistant and hypervirulent clones of Klebsiella pneumoniae: a population biology approach
Description: Klebsiella pneumoniae (Kp) has emerged over the past few decades as a dual risk pathogen. First, it ranks amongst the bacterial pathogens that are the most difficult to treat, due to cumulative acquisition […]
Evaluation of the use of non-invasive tests for early screening and survey of arboviruses
Description: The main objective of this pilot project, Arbo-VIRTUESS is to improve the early screening and survey of the arboviruses. Therefore, we propose to work towards non-invasive samples, i.e. saliva and urine, which could […]
Diagnostic, évolution moléculaire et compétence vectorielle pour Aedes aegypti du virus Zika en Afrique, Asie et dans le Pacifique
Description: Le virus Zika (ZIKV) est un arbovirus de la famille des Flaviviridae. Il est responsable d’une infection similaire à une dengue classique chez l’homme. Il est réparti en Afrique et en Asie du […]
Aedes aegypti, dengue and chikungunya mosquito vector in the Pacific: surveillance and knowledge improvement towards a better control
Description: In the absence of specific treatments and vaccines against dengue fever and chikungunya, the only methods to prevent the transmission of dengue and chikungunya viruses, are to monitor and control the mosquito vectors, […]
Evaluation and scale up process of a new ELISA test for the detection of anti-chikungunya virus IgM
Description: Chikungunya infection is now considered as a major health threat because of its high incidence rate and the severity of the disease during the acute phase. Less than 20% of the patient experienced […]
Résistance aux pyréthrinoïdes chez Aedes aegypti : évaluation de nouveaux candidats insecticides et étude du phénomène de réversion
Description: Aedes aegypti populations are pyrethroid resistant in several French overseas territories, reducing vector control efficacy. The increase of arbovirosis outbreaks worldwide, the development of insecticide resistance and the reduction of authorized molecules urge […]
Emergency response to global threats of emerging and re-emerging pathogens
With over 125 years’ experience with infectious diseases, the Institut Pasteur and the Institut Pasteur International Network (IPIN), which is composed of 33 research institutes in 26 countries and five continents, are ideally positioned […]
Population biology of the bacterial pathogen Klebsiella pneumoniae
Klebsiella pneumoniae is one of the most urgent threats to public health given its increasing resistance to antimicrobial agents including carbapenems, considered as last-resort antibiotics. In this project we aim to understand the ecological, epidemiological and […]
Leptospirosis in Pacific Island states: development of diagnostic capabilities and disease burden assessment.
Description: Leptospirosis is known to be highly prevalent in Futuna and in Fiji, but little is known about its epidemiology and animal reservoirs. Oppositely, the burden of leptospirosis in Vanuatu remains mostly unknown. Because […]
Eco-épidémiologie moléculaire de la Leptospirose
Description: Lors des diagnostics de leptospirose humaine, le sérogroupe infectant est classiquement identifié de façon présomptive par l’antigène donnant le titre le plus élevé dans la réaction sérologique de micro-agglutination (MAT). L’identification du sérogroupe […]
Virulence of Leptospira isolates
Description: The aim of the project is to characterize the virulence of Leptospira strains involved in human cases in New Caledonia. Acronyme: VIRULEPT Goal: The main objective is to identify strain-specific virulence traits or […]
2010Differential cytokine gene expression according to outcome in a hamster model of leptospirosis, PLoS Negl Trop Dis 2010;4(1):e582.
2009Correlation between antibiotic susceptibilities and genotypes in Neisseria gonorrhoeae from different geographical origins: determinants monitoring by real-time PCR as a complementary tool for surveillance, Sex Transm Infect 2010 Apr;86(2):106-11.
2009Outbreak of leptospirosis in New Caledonia: diagnosis issues and burden of disease, Trop. Med. Int. Health 2009 Aug;14(8):926-9.
2009Quinolone resistance in Neisseria gonorrhoeae: rapid genotyping of quinolone resistance-determining regions in gyrA and parC genes by melting curve analysis predicts susceptibility, Antimicrob. Agents Chemother. 2009 Mar;53(3):1264-7.
2008Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae, Antimicrob. Agents Chemother. 2008 Nov;52(11):4155-8.
2008Genotyping as a tool for antibiotic resistance surveillance of Neisseria gonorrhoeae in New Caledonia: evidence of a novel genotype associated with reduced penicillin susceptibility, Antimicrob. Agents Chemother. 2008 Sep;52(9):3293-300.
2006A novel real-time duplex PCR assay for detecting penA and ponA genotypes in Neisseria gonorrhoeae: Comparison with phenotypes determined by the E-test, Clin. Chem. 2006 Dec;52(12):2294-6.
2006Evidence that the gonococcal porA pseudogene is present in a broad range of Neisseria gonorrhoeae strains; suitability as a diagnostic target, Pathology 2006 Oct;38(5):445-8.
2006Proinflammatory and immunomodulatory cytokine mRNA time course profiles in hamsters infected with a virulent variant of Leptospira interrogans, Infect. Immun. 2006 Jul;74(7):4172-9.
2006Rapid detection of a chromosomally mediated penicillin resistance-associated ponA mutation in Neisseria gonorrhoeae using a real-time PCR assay, FEMS Microbiol. Lett. 2006 Feb;255(1):66-74.
+View full list of publications
Location: 9 Avenue Paul Doumer, Noumea, New Caledonia